Musculoskeletal system (the musculoskeletal system, locomotor system) is a complex system of organs of the human body. It is a complex of structures forming the frame, giving shape to the body, giving him support, protecting the internal organs and the possibility of movement in space. The musculoskeletal system consists of active and passive systems. Active musculoskeletal system, is mainly used for movement and consists of skeletal muscles and their initial or subsidiary bodies: the fascia, tendons, synovial bags. Passive musculoskeletal system serves mainly to support soft tissue, the attachment point of the muscle (lever system), receptacle and protection of internal organs and consists of a skeleton with its various parts: bones, cartilage, joints, intervertebral discs, ligaments. The most demanded tissues in the musculoskeletal system is the cartilage.
Cartilage or simply cartilage – a type of connective tissue composed of specialized cells (chondrocytes) and the extracellular matrix. The most important difference of the cartilage from the bone and the absence of cartilage inside the nerves and blood vessels. Cartilage is present in many parts of the human body. In the role of articular cartilage covers the surface of all true joints (Diarthrosen), for example the knee joint and the hip joint. Here she gives a smooth mobility of the joint ends. Even the intervertebral discs (Disci intervertebrales) and menisci are composed of cartilage.
Cartilage cells, rounded chondrocytes support matrix and stored therein singly or in small groups (isogenic groups). The cartilage matrix is composed of 70% water and has virtually no blood vessels and nerves. Its major components are collagen, elastin and proteoglycans, the total number and their exact composition differs depending on the type of cartilage.
The role of the cartilage peptides
The optimal functioning of the musculoskeletal system of the person is directly related to the condition of the cells of cartilage tissues. Modern scientific knowledge to prove that the health of the body depends on the health of individual cells. Function cells are well, then organs and organ systems work well. In order for cells worked well, for example the cells of the cartilage, they must continuously and in sufficient quantity to supply the necessary nutrients. But this one, in accordance with the latest scientific knowledge, is not enough.
For over 30 years, as scientists, doctors discovered that, for the normal functioning of cells, among other things, necessary and peptides. Peptides are small data molecules, short chains of amino acids, the address coordinates of genes. Peptides are formed in the cells of various tissues of the body during protein metabolism. Their main function is to activate the reading of the genetic information in DNA. Thus they initiate protein synthesis in cells and regulate their proper functioning. Scientists have found that deficiency of peptides in the body resulting in impaired functions in cells, cellular dysfunction, accelerated “wear” fabrics, development of pathological conditions and accelerated aging of the body. At the same time, they many studies have shown that the use of peptides and remove deficiency of peptides in the body not only contributes to the regulation of cell functions but even lost cell function can thus be restored.
For normal functions will require the cells of cartilage tissues, among other things, tissue-specific peptides (cartilage peptides) that support and regulate their functions. In a small number of these peptides can be ingested with food, but the main part is formed in the cells, namely the cells of cartilage tissues.
Cells of cartilage tissues produce different types of proteins. Some of them are responsible for the generation of peptides that regulate the cells of cartilage tissues. The peptides of cartilage tissues are components of protein molecules in cartilage tissues. In the metabolism of proteins (the protein fraction) they are removed. One of the most important tasks of these peptides is the activation of the reading of the genetic information of the DNA in the cells of cartilage tissues. Thus peptides play a role in “key DNA”. The peptides of cartilage tissues trigger protein synthesis in the cells of cartilage tissues, regulate metabolism in these cells and regulate their activity. Peptides cause the cell to function as biologically necessary. As a young healthy body. When the cells of cartilage tissues are functioning well, and musculoskeletal system thus runs well. If the normal functions of the cells of cartilage tissue disorders occur, respectively, and musculoskeletal system works poorly. This leads to the dysfunction of the entire musculoskeletal system. Therefore, the corresponding presence of peptides of cartilage tissues in the body, is very important.
The peptides of cartilage tissues trigger protein synthesis in the cells of cartilage tissues, regulate metabolism in these cells and regulate their activity. Peptides cause the cell to function as biologically necessary. As a young healthy body. When the cells of cartilage tissues are functioning well, and musculoskeletal system thus runs well. If the normal functions of the cells of cartilage tissue disorders occur, respectively, and musculoskeletal system works poorly. This leads to the dysfunction of the entire musculoskeletal system. Therefore, the corresponding presence of peptides of cartilage tissues in the body, is very important. This leads to disruption of cell function, development of pathological conditions and accelerated wear of the main systems of the body. The more extreme conditions of the musculoskeletal system, the greater the need for tissue-specific peptides (cartilage peptides) and the faster arise in the cells of cartilage tissues various errors and failures of their functions, if this requirement is not covered properly. This, in turn, can lead to the loss of some important functions of the cells of cartilage tissues and accelerated wear or aging of the musculoskeletal system.
In such situations it is useful to purposefully support cells of cartilage tissues. One of the most effective methods for this is the use of peptides of cartilage tissues of animal origin. In all mammals, the peptides are the same. In numerous studies, scientists have shown that if you take the peptides isolated from the cartilage tissues of animals, for example from calves or pigs, and enter them into the body of another animal or person, they are accepted by the body as its own substance. Peptides have tissue-specific function. That is, they apply only in the tissue from which they were originally allocated. Through the use of cartilage peptides in the body is enriched pool of regulatory peptides of cartilage tissues. Thus, the use of cartilage peptides tissues helps to normalize and maintain a physiologically normal levels of peptides in the cells of cartilage tissues. This, in turn, leads to normalization of metabolism in these cells and normalization of their functions to physiologically normal levels. Normalization of cell function leads to normalization of the functions of cartilage tissues, and therefore functions of the musculoskeletal system.
Peptides from the cartilaginous and osseous tissues – clinical studies
In a clinical study determined the effectiveness of the cartilage tissues peptides for complex functional recovery of locomotor apparatus after diseases of various origins, under pathological conditions, leading to disruption of the function of cartilage, the effects of extreme environmental factors, poor diet, and during aging. In a clinical study it was also found that the use of the cartilage tissue peptides in patients with osteoarthritis of the knee has contributed to the reduction of pain and increase joint mobility in 68.5% of cases. However, most full of pain symptoms disappeared when radiographically defined initial stages of the disease. In patients with osteoporosis with long-term use of the drug was observed stabilization of metabolic processes in cartilage tissue: decreased number of typical fractures, significantly accelerated the recovery process functions of the musculoskeletal system and decreased the time of hospital stay. All the patients showed a significant smoothing of the main symptoms for the occurrence of this group of diseases characterized by conservatism. When using cartilage peptides did not reveal any side effects, complications or contraindications.
Peptides from the cartilaginous and osseous tissues – recommended applications
- complex functional recovery of locomotor apparatus after the diseases of different genesis
- pathological conditions that lead to impairment of cartilage tissue
- arthrosis and arthritis
- impact of extreme environmental factors
- during aging to support the functions of the musculoskeletal system
Areas of applications based on the biological effects of the active substances, included in this product based on scientific evidence and practical experience.
Peptides from the cartilaginous and osseous tissues in preparations
Based on peptides derived from the cartilaginous and osseous tissues of young, healthy animals, are produced as a medication in the form of injectable solutions, tablets or capsules and biologically active food supplements.
The peptides of the cartilaginous and osseous tissues can contain up to 100 amino acids. But the active portion of the peptide is very small and usually contains up to 4 amino acids, all other regulatory action is not significant. When selecting products with peptides cartilaginous and osseous tissues, you must pay attention to the fact that they used the most short peptides. They have less inactive parts and are thus better permeability and regulatory properties. We use only the peptides obtained by the method of the latest patented technology, with a molecular mass of 10 kDa. Preparations on the basis of these peptides have the best values currently in the regulation, and, therefore, also called bioregulators. It is on the basis of such peptides made our products.
Peptides derived from cartilaginous and osseous tissues of healthy, young animals are used in our biologically active food supplements IPH-AEN®.
Biologically active food supplements on the basis of peptides isolated from the cartilaginous and osseous tissues are extremely safe to use. Because peptides are endogenous substances (produced in the body) and the cell cannot take more peptides than that given to her by nature, the use of peptides may not result whether to overdose whether to cause any side effects. It should be understood that the peptides have a very soft action which develops only with adequate enrichment (peptide level) of certain peptides in the body. For many years, the peptides had more than 15 million people. In all that time none of this man have not observed any contraindications or other side effects.